DSpace community: 生醫理工學院

解碼動作心智模擬：動作心像驅動學習歷程之神經動態與可塑性機制;Decoding Mental Simulation of Actions: Mechanisms of Imagery-Driven Neural Dynamics and Plasticity for Motor Learning

Mon, 27 Jul 2026 07:48:36 GMT

title: 解碼動作心智模擬：動作心像驅動學習歷程之神經動態與可塑性機制;Decoding Mental Simulation of Actions: Mechanisms of Imagery-Driven Neural Dynamics and Plasticity for Motor Learning abstract: 本計畫之執行目的在於解決動作想像研究領域中長久以來的理論分歧與驗證困難，並建立具神經生理效度的整合性架構。具體目標包含三點：首先是建立「情境依賴架構」，打破動作想像與實際執行完全功能等價的傳統觀點，證明神經重疊程度受任務複雜度與認知資源調節；其次是解決「驗證問題」，開發穩態體感誘發電位（SSSEP）作為客觀生理指標，利用感覺門控機制即時監測受試者是否真實進行內在模擬；最後是解碼「靜默可塑性」，探討在無身體回饋下，大腦如何透過虛擬預測誤差更新內部模型。在預期影響性方面，本計畫預計在社會、臨床與產業面向產生具體貢獻。在臨床醫療與社會面，本研究提出的精準神經復健概念，將協助治療師利用客觀生理指標篩選適合的患者，避免對頂葉受損或認知疲勞者進行無效的想像治療，從而優化醫療資源配置並提升中風復健成效。在產業與經濟發展面，本計畫開發的 SSSEP 頻率標記技術可直接轉化應用於優化混合式腦機介面（Hybrid BCI）系統，提供比傳統技術更高的訊號雜訊比，有助於開發更可靠的溝通與控制輔具，以對應高齡化社會與嚴重動作障礙患者的需求。在學術研究面，則能整合現有分歧的理論模型，並提供如觸發啟動典範等創新實驗方法供後續研究使用。

大腦皮質雙穩態與注意力缺失：清醒慢波的經顱磁刺激-腦電圖研究;Cortical Bistability and Attention Lapses: a Tms-Eeg Investigation of Wake Slow Waves

Mon, 27 Jul 2026 07:48:00 GMT

title: 大腦皮質雙穩態與注意力缺失：清醒慢波的經顱磁刺激-腦電圖研究;Cortical Bistability and Attention Lapses: a Tms-Eeg Investigation of Wake Slow Waves abstract: This project aims to establish the first comprehensive mechanistic account linking wake slow waves, cortical bistability, and attention lapses, advancing fundamental understanding of the neural mechanisms underlying human cognitive performance. Attention deficits are core symptoms of numerous neurological and psychiatric conditions, including depression, sleep disorders, and early-stage neurodegenerative diseases. Current treatments often lack precision because the underlying neural mechanisms remain poorly understood. By identifying objective neural markers of attention lapses, this research may contribute to improved diagnostic tools that detect attention impairments before they manifest behaviorally, personalized treatment approaches that target specific neural mechanisms rather than symptoms, and objective monitoring of treatment efficacy through neural biomarkers of cortical bistability. The TMS-EEG methodology developed in this project also has potential therapeutic applications. Understanding how different brain regions respond to stimulation across cognitive states may inform the development of targeted brain stimulation protocols for patients with pathological attention deficits. These findings may ultimately benefit patients whose quality of life is compromised by attention-related difficulties in work, education, and daily functioning.

應用動態細胞培養系統與3D培養皿來探討HFpEF的病態生理機轉-基礎與臨床試驗;Investigating the Pathophysiological Mechanisms of Hfpef Using a Dynamic Cell Culture System and 3d Culture Plates: from Basic Research to Clinical Trials

Mon, 27 Jul 2026 07:18:38 GMT

title: 應用動態細胞培養系統與3D培養皿來探討HFpEF的病態生理機轉-基礎與臨床試驗;Investigating the Pathophysiological Mechanisms of Hfpef Using a Dynamic Cell Culture System and 3d Culture Plates: from Basic Research to Clinical Trials abstract: 仿生心肌平台＋臨床資料整合＋可解釋 AI」為核心，預期可同時提升 HFpEF 機轉研究的可信度與藥物研發的轉譯效率，並在社會健康、醫療支出、以及生醫產業創新與技轉落地等面向產生具體效益。

結合表面改質材料與藥物包覆系統應用於抑制術後血管內膜增生;The Application of Combined Surface Modification Materials and Drug Coating Systems for Inhibiting Postoperative Vascular Intimal Hyperplasia

Mon, 27 Jul 2026 07:18:29 GMT

title: 結合表面改質材料與藥物包覆系統應用於抑制術後血管內膜增生;The Application of Combined Surface Modification Materials and Drug Coating Systems for Inhibiting Postoperative Vascular Intimal Hyperplasia abstract: 鑒於目前臨床上並無解決術後血管內膜增生的方法而只能以給予抗凝劑、抗血小板藥物等方式來改善因血管再狹窄而發生阻塞的情形, 本研究計畫旨在開發一絲裂黴素C接枝縫線結合載比伐努定之Carbopol 940膠的新型治療方法。此改良縫線系統可望降低術後血管內膜的增生，以避免因血管再狹窄而發生阻塞。若能成功開發，預計能提高臨床治療的整體效率並降低相關併發症所帶來的長期醫療成本，同時減輕患者家庭和社會的經濟負擔。而透過本研究亦能深化對抗血管內膜增生相關機制的理解，或能在日後為其他疾病研究借鑒，推動領域的學術進展。也期待藉由本研究計劃的成果能提升產業界對於此議題之關注度，促進更多相關醫材的開發與商化，提升患者的醫療品質與生活福祉。