Two-layer architecture using atom transfer radical polymerization for enhanced sensing and detection in complex media

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题名:	Two-layer architecture using atom transfer radical polymerization for enhanced sensing and detection in complex media
作者:	黃俊仁;Brault, Norman D;Sundaram, Harihara S;Huang, Chun-Jen;Li, Yuting;Yu, Qiuming;Jiang, Shaoyi
贡献者:	工學院化學工程與材料工程學系
关键词:	Acrylamides - chemical synthesis;antibodies;Antibodies, Immobilized;Antibodies, Monoclonal - blood;antigens;Applied sciences;biochemical compounds;Biological and medical sciences;Biosensing Techniques - instrumentation;Biosensing Techniques - methods;Biosensors;Biotechnology;blood;Calibration;chemical elements;coatings;diagnostic techniques;Exact sciences and technology;Fundamental and applied biological sciences. Psychology;Humans;Methods. Procedures. Technologies;Molecular Structure;Organic polymers;Physicochemistry of polymers;Polymerization;polymers;Polymers - chemical synthesis;Polymers with particular structures;Preparation, kinetics, thermodynamics, mechanism and catalysts;sodium azide;Surface Plasmon Resonance;Surface Properties;Thyrotropin - blood;Various methods and equipments;zwitterions
日期:	2012-12-10
上传时间:	2026-04-21 14:04:26 (UTC+8)
出版者:	American Chemical Society;Washington, DC: American Chemical Society
摘要:	摘要： A novel, two-layer hierarchical architecture based on surface-initiated atom transfer radical polymerization was investigated. It combines a thin and highly dense first layer, for nonfouling properties, with a loose second layer for high immobilization levels of active biomolecules. Sodium azide treatment, to reduce the concentration of macroinitiators on the first layer for reinitiation, and by controlling the polydispersity allowed one to achieve three polymer architectures with low, moderate, or high azide substitution. Moderate substitution enabled the highest immobilization levels with a nonfouling background. Integration with dual-functional zwitterionic poly(carboxybetaine) made this platform suitable for applications in undiluted complex media such as blood. It was demonstrated via a surface plasmon resonance biosensor that antigen accessibility and antibody loading were greatly improved. These results indicate the two-layer strategy as a generic concept suitable for applications from diagnostics to medical coatings in order to maximize and minimize specific and nonspecific responses, respectively. 其他題名： Biomacromolecules 出版者： Washington, DC: American Chemical Society 出版日期： 2012-12-10 出處： Biomacromolecules, 2012-12, Vol.13 (12), p.4049-4056 資源來源： American Chemical Society Publications 版權： Copyright © 2012 American Chemical Society 版權： 2014 INIST-CNRS 識別號： ISSN: 1525-7797 識別號： ISSN: 1526-4602 識別號： EISSN: 1526-4602 識別號： DOI: 10.1021/bm301335r 識別號： PMID: 23101430
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