Colloidosomes formed by nonpolar/polar/nonpolar nanoball amphiphiles

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题名:	Colloidosomes formed by nonpolar/polar/nonpolar nanoball amphiphiles
作者:	曹恆光;Chang, Hung-Yu;Tu, Sheng-Hung;Sheng, Yu-Jane;Tsao, Heng-Kwong
贡献者:	工學院化學工程與材料工程學系
关键词:	AQUEOUS SOLUTIONS;ARMS;Bilayers;Colloids - chemistry;Computer Simulation;FULLERENES;Fullerenes - chemistry;Hydrophobic and Hydrophilic Interactions;Hydrophobicity;INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;LIPOSOMES;MECHANICAL PROPERTIES;MEMBRANES;Micelles;Models, Chemical;Models, Molecular;Molecular Conformation;Nanospheres - chemistry;Nanospheres - ultrastructure;Order parameters;POLYMERS;Self-assembly;SIMULATION;SOLVENTS;Static Electricity;Vesicles;Water - chemistry
日期:	2014-08-07
上传时间:	2026-04-21 14:27:36 (UTC+8)
出版者:	American Institute of Physics;United States: American Institute of Physics
摘要:	摘要： Fullerene-based amphiphiles are able to form bilayer vesicles in aqueous solution. In this study, the self-assembly behavior of polymer-tethered nanoballs (NBs) with nonpolar/polar/nonpolar (n-p-n′) motif in a selective solvent is investigated by dissipative particle dynamics. A model NB bears two hydrophobic polymeric arms (n′-part) tethered on an extremely hydrophobic NB (n-part) with hydrophilic patch (p-part) patterned on its surface. Dependent on the hydrophobicity and length of tethered arms, three types of aggregates are exhibited, including NB vesicle, core-shell micelle, and segmented-worm. NB vesicles are developed for a wide range of hydrophobic arm lengths. The presence of tethered arms perturbs the bilayer structure formed by NBs. The structural properties including the order parameter, membrane thickness, and area density of the inner leaflet decrease with increasing the arm length. These results indicate that for NBs with longer arms, the extent of interdigitation in the membrane rises so that the overcrowded arms in the inner corona are relaxed. The transport and mechanical properties are evaluated as well. As the arm length grows, the permeability increases significantly because the steric bulk of tethered arms loosens the packing of NBs. By contrast, the membrane tension decreases owing to the reduction of NB/solvent contacts by the polymer corona. Although fusion can reduce membrane tension, NB vesicles show strong resistance to fusion. Moreover, the size-dependent behavior observed in small liposomes is not significant for NB vesicles due to isotropic geometry of NB. Our simulation results are consistent with the experimental findings. 其他題名： J Chem Phys 出版者： United States: American Institute of Physics 出版日期： 2014-08-07 出處： The Journal of chemical physics, 2014-08, Vol.141 (5), p.054906 資源來源： AIP Journals (American Institute of Physics) 版權： 2014 AIP Publishing LLC. 識別號： ISSN: 0021-9606 識別號： ISSN: 1089-7690 識別號： EISSN: 1089-7690 識別號： DOI: 10.1063/1.4891516 識別號： PMID: 25106612
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