Bioinspired Zwitterionic Surface Coatings with Robust Photostability and Fouling Resistance

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题名:	Bioinspired Zwitterionic Surface Coatings with Robust Photostability and Fouling Resistance
作者:	黃俊仁;Huang, Chun-Jen;Chu, Sz-Hau;Wang, Lin-Chuan;Li, Chien-Hung;Lee, T. Randall
贡献者:	工學院化學工程與材料工程學系
关键词:	adsorption;Adsorption - drug effects;Amino Acids - chemistry;bacteria;betaine;Betaine - chemical synthesis;Betaine - chemistry;Betaine - pharmacology;Biofouling;coatings;copper;cysteine;Cysteine - chemical synthesis;Cysteine - chemistry;Cysteine - pharmacology;Equipment and Supplies;fibroblasts;gold;Gold - chemistry;Hydrophobic and Hydrophilic Interactions;medical equipment;nanoparticles;oxidation;photostability;Polymers - chemistry;proteins;Serum Albumin, Bovine - chemistry;Serum Albumin, Bovine - drug effects;Surface Properties - drug effects;zwitterions
日期:	2015-10-09
上传时间:	2026-04-21 14:40:19 (UTC+8)
出版者:	American Chemical Society;United States: American Chemical Society
摘要:	摘要： Great care has been paid to the biointerface between a bulk material and the biological environment, which plays a key role in the optimized performance of medical devices. In this work, we report a new superhydrophilic adsorbate, called l-cysteine betaine (Cys-b), having branched zwitterionic groups that give rise to surfaces and nanoparticles with enhanced chemical stability, biofouling resistance, and inertness to environmental changes. Cys-b was synthesized from the amphoteric sulfur-containing amino acid, l-cysteine (Cys), by quaternization of its amino group. Gold surfaces modified with Cys-b exhibited prominent repellence against the nonspecific adsorption of proteins, bacteria, and fibroblast cells. In addition, Cys-b existed in zwitterionic form over a wide pH range (i.e., pH 3.4 to 10.8), and showed excellent suppression in photoinduced oxidation on gold substrates. Furthermore, the modification of hollow AgAu nanoshells with Cys-b gave rise to nanoparticles with excellent colloidal stability and resistance to coordinative interaction with Cu2+. Taken together, the unique features of Cys-b offer a new nanoscale coating for use in a wide spectrum of applications. 其他題名： ACS Appl. Mater. Interfaces 出版者： United States: American Chemical Society 出版日期： 2015-10-28 出處： ACS applied materials & interfaces, 2015-10, Vol.7 (42), p.23776-23786 資源來源： American Chemical Society Journals 版權： Copyright © 2015 American Chemical Society 識別號： ISSN: 1944-8244 識別號： ISSN: 1944-8252 識別號： EISSN: 1944-8252 識別號： DOI: 10.1021/acsami.5b08418 識別號： PMID: 26452141
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