摘要： Using frequency and rank order statistics (FROS), this study analyzed the fluctuations in arterial waveform amplitudes recorded from an air pressure sensing system before and after reactive hyperemia (RH) induction by temporary blood flow occlusion to evaluate the vascular endothelial function of aged and diabetic subjects. The modified probability-weighted distance (PWD) calculated from the FROS was compared with the dilatation index (DI) to evaluate its validity and sensitivity in the assessment of vascular endothelial function. The results showed that the PWD can provide a quantitative determination of the structural changes in the arterial pressure signals associated with regulation of vascular tone and blood pressure by intact vascular endothelium after the application of occlusion stress. Our study suggests that the use of FROS is a reliable noninvasive approach to the assessment of vascular endothelial degeneration in aging and diabetes. •Changes should appear when endothelium regulates blood vessel after occlusion.•DM is an important contributor to atherosclerosis.•First clinical application of FROS in assessing endothelial function in DM. 出版者： Elsevier B.V 出版日期： 2013-08-01 出處： Physica A, 2013-08, Vol.392 (15), p.3122-3131 版權： 2013 Elsevier B.V. 識別號： ISSN: 0378-4371 識別號： EISSN: 1873-2119 識別號： DOI: 10.1016/j.physa.2013.03.033
