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| Title: | Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia |
| Authors: | 羅孟宗;Wu, Hsien-Tsai;Hsu, Po-Chun;Sun, Cheuk-Kwan;Wang, Hou-Jun;Liu, Cyuan-Cin;Chen, Hong-Ruei;Liu, An-Bang;Tang, Chieh-Ju;Lo, Men-Tzung |
| Contributors: | 生醫理工學院生醫科學與工程學系 |
| Keywords: | Adolescent;Adult;Aged;Aged, 80 and over;atherosclerosis;atmospheric pressure;Autonomic dysfunction;Diabetes Mellitus, Type 2;Diabetes Mellitus, Type 2 - pathology;Diabetes Mellitus, Type 2 - physiopathology;Endothelium, Vascular;Endothelium, Vascular - pathology;Endothelium, Vascular - physiopathology;Female;heart rate;Humans;Hyperemia;Hyperemia - pathology;Hyperemia - physiopathology;Male;microsatellite repeats;Middle Aged;middle-aged adults;noninsulin-dependent diabetes mellitus;pathology;patients;physiopathology;Poincar� method;Pulse rate variability;SD1/SD2 ratio (SSR) |
| Date: | 2013-08-07 |
| Issue Date: | 2026-04-23 11:15:10 (UTC+8) |
| Publisher: | Academic Press Inc.;England: Elsevier Ltd |
| Abstract: | 摘要： It is known that aging and type 2 diabetes mellitus contribute to atherosclerosis and autonomic dysfunction. By using the air pressure sensing system (APSS), peak–peak intervals (PPIs) of wrist arterial waveforms from baseline and reactive hyperemia (RH) were obtained. Through frequency domain analysis of heart rate variability (HRV) and nonlinear Poincaré method, the HRV of healthy young individuals (Group 1, n=25), healthy upper middle-aged individuals (Group 2, n=22), and patients with type 2 diabetes (Group 3, n=28) were assessed. By using the standard deviation (SD) of the instantaneous PPI variability (SD1)/the SD of the long PPI variability (SD2) ratio (SSR), PPIs of the same individuals before and after RH induction were compared. Reduced SSR1–10 was noted only in patients with diabetes. Moreover, a significient correlation between SSR1–10 and endothelial function was observed in all subjects (r=0.290, p=0.033) after RH. However, no correlation with low-frequency to high-frequency power ratio (LHR) was noted before and after RH. In conclusion, according to our results, campared to the baseline, there were more significant changes of SSR1–10 after RH in patients with diabetes; and, a significient correlation between SSR1–10 and endothelial function at the moment of RH was noted. •Diabetes is an important contributor to atherosclerosis and autonomic dysfunction.•The study assessed autonomic function in healthy and diabetes subjects.•Endothelial function is associated with autonomic function after reactive hyperemia.
其他題名： J Theor Biol
出版者： England: Elsevier Ltd
出版日期： 2013-08-07
出處： Journal of theoretical biology, 2013-08, Vol.330, p.9-17
版權： 2013 Elsevier Ltd
版權： Copyright © 2013 Elsevier Ltd. All rights reserved.
識別號： ISSN: 0022-5193
識別號： ISSN: 1095-8541
識別號： EISSN: 1095-8541
識別號： DOI: 10.1016/j.jtbi.2013.03.022
識別號： PMID: 23583956 |
| Appears in Collections: | [Department of Biomedical Sciences and Engineering ] journal & Dissertation
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