Heart rhythm complexity impairment in patients undergoing peritoneal dialysis

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题名:	Heart rhythm complexity impairment in patients undergoing peritoneal dialysis
作者:	羅孟宗;Lin, Yen-Hung;Lin, Chen;Ho, Yi-Heng;Wu, Vin-Cent;Lo, Men-Tzung;Hung, Kuan-Yu;Liu, Li-Yu Daisy;Lin, Lian-Yu;Huang, Jenq-Wen;Peng, Chung-Kang
贡献者:	生醫理工學院生醫科學與工程學系
关键词:	639/766/530/2803;692/4022/1950/1724;Cardiovascular disease;Cardiovascular diseases;Creatinine;Dialysis;Ejection fraction;Entropy;Fourier transforms;Heart rate;Hemodialysis;Humanities and Social Sciences;Kidney diseases;Medicine;Mortality;multidisciplinary;Nervous system;Peritoneal dialysis;Renal function;Science;Science (multidisciplinary)
日期:	2016-06-21
上传时间:	2026-04-23 11:16:16 (UTC+8)
出版者:	Nature Publishing Group;London: Nature Publishing Group UK
摘要:	摘要： Cardiovascular disease is one of the leading causes of death in patients with advanced renal disease. The objective of this study was to investigate impairments in heart rhythm complexity in patients with end-stage renal disease. We prospectively analyzed 65 patients undergoing peritoneal dialysis (PD) without prior cardiovascular disease and 72 individuals with normal renal function as the control group. Heart rhythm analysis including complexity analysis by including detrended fractal analysis (DFA) and multiscale entropy (MSE) were performed. In linear analysis, the PD patients had a significantly lower standard deviation of normal RR intervals (SDRR) and percentage of absolute differences in normal RR intervals greater than 20 ms (pNN20). Of the nonlinear analysis indicators, scale 5, area under the MSE curve for scale 1 to 5 (area 1–5) and 6 to 20 (area 6–20) were significantly lower than those in the control group. In DFA anaylsis, both DFA α1 and DFA α2 were comparable in both groups. In receiver operating characteristic curve analysis, scale 5 had the greatest discriminatory power for two groups. In both net reclassification improvement model and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of SDRR, pNN20, and pNN50. In conclusion, PD patients had worse cardiac complexity parameters. MSE parameters are useful to discriminate PD patients from patients with normal renal function. 其他題名： Sci Rep 出版者： London: Nature Publishing Group UK 出版日期： 2016-06-21 出處： Scientific reports, 2016-06, Vol.6 (1), p.28202-28202, Article 28202 資源來源： ProQuest Publicly Available Content Database 版權： The Author(s) 2016 版權： Copyright Nature Publishing Group Jun 2016 版權： Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited 識別號： ISSN: 2045-2322 識別號： EISSN: 2045-2322 識別號： DOI: 10.1038/srep28202 識別號： PMID: 27324066
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