摘要： New epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis. In this study, we applied padlock probe-based ultra-deep bisulfite sequencing for fine mapping of modified cytosines of the HLA complex group 9 (nonprotein coding) gene in the postmortem brains of individuals affected with schizophrenia or bipolar disorder and unaffected controls. Significant differences between patients and controls were detected in both CpG and CpH modifications. In addition, we identified epigenetic age effects, DNA modification differences between sense and anti-sense strands, and demonstrated how DNA modification data can be used in clustering of patient populations. Our findings revealed new epigenetic complexities but also highlighted the potential of DNA modification approaches in the search of heterogeneous causes of major psychiatric disease. 其他題名： Schizophr Bull 出版者： United States: Oxford University Press 出版日期： 2016-01-01 出處： Schizophrenia bulletin, 2016-01, Vol.42 (1), p.sbv079-177 版權： The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. 版權： The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. 2015 識別號： ISSN: 0586-7614 識別號： ISSN: 1745-1701 識別號： EISSN: 1745-1701 識別號： DOI: 10.1093/schbul/sbv079 識別號： PMID: 26078387
