Impaired Cerebral Autoregulation Is Associated with Brain Atrophy and Worse Functional Status in Chronic Ischemic Stroke

NCU Institutional Repository > 生醫理工學院 > 生醫科學與工程學系 > 期刊論文 > Item 987654321/102771

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.lib.ncu.edu.tw/handle/987654321/102771

题名:	Impaired Cerebral Autoregulation Is Associated with Brain Atrophy and Worse Functional Status in Chronic Ischemic Stroke
作者:	羅孟宗;Aoi, Mikio C.;Hu, Kun;Lo, Men-Tzung;Selim, Magdy;Olufsen, Mette S.;Novak, Vera
贡献者:	生醫理工學院生醫科學與工程學系
关键词:	Activities of Daily Living;Adults;Aged;Arterial Pressure;Atrophy;Blood;Blood flow;Blood Flow Velocity;Blood pressure;Brain;Brain - blood supply;Brain - pathology;Brain - physiopathology;Brain Ischemia - complications;Brain Ischemia - physiopathology;Brain research;Cardiology;Cerebral blood flow;Cerebral ischemia;Cerebrovascular Circulation;Chronic Disease;Diabetes;Engineering;Family medical history;Female;Flow velocity;Functional magnetic resonance imaging;Gait;Homeostasis;Humans;Hypertension;Infarction, Middle Cerebral Artery - pathology;Infarction, Middle Cerebral Artery - physiopathology;Ischemia;Lobes;Logistic Models;Magnetic Resonance Imaging;Male;Medicine;Middle Aged;Neurology;NMR;Nuclear magnetic resonance;Older people;Perfusion;Perfusion (Physiology);Physiology;Retrospective Studies;Stroke;Stroke - complications;Stroke - physiopathology;Studies;Substantia grisea;Temporal lobe;Temporal Lobe - blood supply;Temporal Lobe - pathology;Temporal Lobe - physiopathology;Territory;Transplants & implants;Veins & arteries
日期:	2012-10-11
上传时间:	2026-04-23 11:16:22 (UTC+8)
出版者:	Public Library of Science;United States: Public Library of Science
摘要:	摘要： Dynamic cerebral autoregulation (dCA) is impaired following stroke. However, the relationship between dCA, brain atrophy, and functional outcomes following stroke remains unclear. In this study, we aimed to determine whether impairment of dCA is associated with atrophy in specific regions or globally, thereby affecting daily functions in stroke patients.We performed a retrospective analysis of 33 subjects with chronic infarctions in the middle cerebral artery territory, and 109 age-matched non-stroke subjects. dCA was assessed via the phase relationship between arterial blood pressure and cerebral blood flow velocity. Brain tissue volumes were quantified from MRI. Functional status was assessed by gait speed, instrumental activities of daily living (IADL), modified Rankin Scale, and NIH Stroke Score.Compared to the non-stroke group, stroke subjects showed degraded dCA bilaterally, and showed gray matter atrophy in the frontal, parietal and temporal lobes ipsilateral to infarct. In stroke subjects, better dCA was associated with less temporal lobe gray matter atrophy on the infracted side ([Formula: see text] = 0.029), faster gait speed ([Formula: see text] = 0.018) and lower IADL score ([Formula: see text]0.002). Our results indicate that better dynamic cerebral perfusion regulation is associated with less atrophy and better long-term functional status in older adults with chronic ischemic infarctions. 其他題名： PLoS One 出版者： United States: Public Library of Science 出版日期： 2012-10-11 出處： PloS one, 2012-10, Vol.7 (10), p.e46794 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2012 Public Library of Science 版權： Aoi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2012 Aoi et al 2012 Aoi et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0046794 識別號： PMID: 23071639
显示于类别:	[生醫科學與工程學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	30	检视/开启

在NCUIR中所有的数据项都受到原著作权保护.

社群 sharing

数据加载中.....