中大學術數位典藏-NCU Institutional Repository:Item 987654321/102870
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    题名: Outlier-resilient complexity analysis of heartbeat dynamics
    作者: 羅孟宗;Lo, Men-Tzung;Chang, Yi-Chung;Lin, Chen;Young, Hsu-Wen Vincent;Lin, Yen-Hung;Ho, Yi-Lwun;Peng, Chung-Kang;Hu, Kun
    贡献者: 生醫理工學院生醫科學與工程學系
    关键词: 631/57/2266;639/766/530/2804;639/766/747;692/53/2422;Congestive heart failure;Electrocardiography;Heart - physiology;Heart Diseases - physiopathology;Heart Rate;Humanities and Social Sciences;Humans;Models, Biological;multidisciplinary;Physiology;Science;Time series
    日期: 2015-03-06
    上传时间: 2026-04-23 11:18:29 (UTC+8)
    出版者: Nature Publishing Group;London: Nature Publishing Group UK
    摘要: 摘要: Complexity in physiological outputs is believed to be a hallmark of healthy physiological control. How to accurately quantify the degree of complexity in physiological signals with outliers remains a major barrier for translating this novel concept of nonlinear dynamic theory to clinical practice. Here we propose a new approach to estimate the complexity in a signal by analyzing the irregularity of the sign time series of its coarse-grained time series at different time scales. Using surrogate data, we show that the method can reliably assess the complexity in noisy data while being highly resilient to outliers. We further apply this method to the analysis of human heartbeat recordings. Without removing any outliers due to ectopic beats, the method is able to detect a degradation of cardiac control in patients with congestive heart failure and a more degradation in critically ill patients whose life continuation relies on extracorporeal membrane oxygenator (ECMO). Moreover, the derived complexity measures can predict the mortality of ECMO patients. These results indicate that the proposed method may serve as a promising tool for monitoring cardiac function of patients in clinical settings.
    其他題名: Sci Rep
    出版者: London: Nature Publishing Group UK
    出版日期: 2015-03-06
    出處: Scientific reports, 2015-03, Vol.5 (1), p.8836-8836, Article 8836
    資源來源: ProQuest Open Access Content Collection
    版權: The Author(s) 2015
    版權: Copyright Nature Publishing Group Mar 2015
    版權: Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved
    識別號: ISSN: 2045-2322
    識別號: EISSN: 2045-2322
    識別號: DOI: 10.1038/srep08836
    識別號: PMID: 25744292
    显示于类别:[生醫科學與工程學系] 期刊論文

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