Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure

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题名:	Application of nitrogen plasma immersion ion implantation to titanium nasal implants with nanonetwork surface structure
作者:	李勝偉;Sun, Ying-Sui;Zhang, Lan;Zhu, Hongqin;Yang, Wei-En;Lan, Ming-Ying;Lee, Sheng-Wei;Huang, Her-Hsiung
贡献者:	工學院材料科學與工程研究所
关键词:	60 APPLIED LIFE SCIENCES;ANODIZATION;BLOOD;ELECTROCHEMISTRY;ENGINEERING;HUMAN POPULATIONS;IMPLANTS;ION IMPLANTATION;MORPHOLOGY;NANOSTRUCTURES;NITROGEN;NOSE;PLASMA;ROUGHNESS;SURFACES;THICKNESS;THIN FILMS;TITANIUM;TITANIUM NITRIDES;WETTABILITY
日期:	2016-07-01
上传时间:	2026-04-23 11:28:42 (UTC+8)
出版者:	AVS Science and Technology Society;United States
摘要:	摘要： In nasal reconstruction, the response of cells to titanium (Ti) implants is mainly determined by surface features of the implant. In a pilot study, the authors applied electrochemical anodization to Ti surfaces in an alkaline solution to create a network of nanoscale surface structures. This nanonetwork was intended to enhance the responses of primary human nasal epithelial cell (HNEpC) to the Ti surface. In this study, the authors then treated the anodized, nanonetwork-structured Ti surface using nitrogen plasma immersion ion implantation (NPIII) in order to further improve the HNEpC response to the Ti surface. Subsequently, surface characterization was performed to elucidate morphology, roughness, wettability, and chemistry of specimens. Cytotoxicity, blood, and HNEpC responses were also evaluated. Our results demonstrate that NPIII treatment led to the formation of a noncytotoxic TiN-containing thin film (thickness <100 nm) on the electrochemically anodized Ti surface with a nanonetwork-structure. NPIII treatment was shown to improve blood clotting and the adhesion of platelets to the anodized Ti surface as well as the adhesion and proliferation of hNEpC. This research spreads our understanding of the fact that a TiN-containing thin film, produced using NPIII treatment, could be used to improve blood and HNEpC responses to anodized, nanonetwork-structured Ti surfaces in nasal implant applications. 出版者： United States 出版日期： 2016-07-01 出處： Journal of vacuum science & technology. A, Vacuum, surfaces, and films, 2016-07, Vol.34 (4) 資源來源： AIP Journals CAUL Collection 版權： American Vacuum Society 識別號： ISSN: 0734-2101 識別號： EISSN: 1520-8559 識別號： DOI: 10.1116/1.4953409 識別號： CODEN: JVTAD6
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