A critical role of temporoparietal junction in the integration of top-down and bottom-up attentional control

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Title:	A critical role of temporoparietal junction in the integration of top-down and bottom-up attentional control
Authors:	阮啓弘;Wu, Qiong;Chang, Chi-Fu;Xi, Sisi;Huang, I-Wen;Liu, Zuxiang;Juan, Chi-Hung;Wu, Yanhong;Fan, Jin
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Adult;Attention - physiology;attentional control;Brain Mapping - methods;Executive Function - physiology;Female;fMRI;Goals;Humans;interaction;Magnetic Resonance Imaging;Male;Parietal Lobe - physiology;tDCS;Temporal Lobe - physiology;temporoparietal junction;Transcranial Magnetic Stimulation;Young Adult
Date:	2015-11-01
Issue Date:	2026-04-23 14:17:47 (UTC+8)
Publisher:	Wiley-Liss Inc.;United States: Blackwell Publishing Ltd
Abstract:	摘要： AbstractInformation processing can be biased toward behaviorally relevant and salient stimuli by top‐down (goal‐directed) and bottom‐up (stimulus‐driven) attentional control processes respectively. However, the neural basis underlying the integration of these processes is not well understood. We employed functional magnetic resonance imaging (fMRI) and transcranial direct‐current stimulation (tDCS) in humans to examine the brain mechanisms underlying the interaction between these two processes. We manipulated the cognitive load involved in top‐down processing and stimulus surprise involved in bottom‐up processing in a factorial design by combining a majority function task and an oddball paradigm. We found that high cognitive load and high surprise level were associated with prolonged reaction time compared to low cognitive load and low surprise level, with a synergistic interaction effect, which was accompanied by a greater deactivation of bilateral temporoparietal junction (TPJ). In addition, the TPJ displayed negative functional connectivity with right middle occipital gyrus, which is involved in bottom‐up processing (modulated by the interaction effect), and the right frontal eye field (FEF), which is involved in top‐down control. The enhanced negative functional connectivity between the TPJ and right FEF was accompanied by a larger behavioral interaction effect across subjects. Application of cathodal tDCS over the right TPJ eliminated the interaction effect. These results suggest that the TPJ plays a critical role in processing bottom‐up information for top‐down control of attention. Hum Brain Mapp 36:4317–4333, 2015. © 2015 Wiley Periodicals, Inc. 其他題名： Hum. Brain Mapp 出版者： United States: Blackwell Publishing Ltd 出版日期： 2015-11 出處： Human Brain Mapping, 2015-11, Vol.36 (11), p.4317-4333 資源來源： Alma/SFX Local Collection 版權： 2015 Wiley Periodicals, Inc. 識別號： ISSN: 1065-9471 識別號： ISSN: 1097-0193 識別號： EISSN: 1097-0193 識別號： DOI: 10.1002/hbm.22919 識別號： PMID: 26308973
Appears in Collections:	[College of Science Institute of Cognitive Neuroscience] journal & Dissertation

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