An unavoidable modulation? Sensory attention and human primary motor cortex excitability

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Title:	An unavoidable modulation? Sensory attention and human primary motor cortex excitability
Authors:	馬杰仁;Ruge, Diane;Muggleton, Neil;Hoad, Damon;Caronni, Antonio;Rothwell, John C.
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Adult;attention;Attention - physiology;cognition;Cognition - physiology;cortex;Cues;Discrimination (Psychology) - physiology;Electric Stimulation;Evoked Potentials, Motor;Executive Function - physiology;Female;gamma-Aminobutyric Acid - metabolism;Hand - physiology;human;Humans;Male;motor control;Motor Cortex - physiology;Muscle, Skeletal - physiology;Neural Inhibition - physiology;Neuropsychological Tests;Photic Stimulation;Touch Perception - physiology;Visual Perception - physiology
Date:	2014-01-01
Issue Date:	2026-04-23 14:19:25 (UTC+8)
Publisher:	France: Blackwell Publishing Ltd
Abstract:	摘要： The link between basic physiology and its modulation by cognitive states, such as attention, is poorly understood. A significant association becomes apparent when patients with movement disorders describe experiences with changing their attention focus and the fundamental effect that this has on their motor symptoms. Moreover, frequently used mental strategies for treating such patients, e.g. with task‐specific dystonia, widely lack laboratory‐based knowledge about physiological mechanisms. In this largely unexplored field, we looked at how the locus of attention, when it changed between internal (locus hand) and external (visual target), influenced excitability in the primary motor cortex (M1) in healthy humans. Intriguingly, both internal and external attention had the capacity to change M1 excitability. Both led to a reduced stimulation‐induced GABA‐related inhibition and a change in motor evoked potential size, i.e. an overall increased M1 excitability. These previously unreported findings indicated: (i) that cognitive state differentially interacted with M1 physiology, (ii) that our view of distraction (attention locus shifted towards external or distant location), which is used as a prevention or management strategy for use‐dependent motor disorders, is too simple and currently unsupported for clinical application, and (iii) the physiological state reached through attention modulation represents an alternative explanation for frequently reported electrophysiology findings in neuropsychiatric disorders, such as an aberrant inhibition. Pure sensory attention without any motor component changes excitability in the motor cortex. Both, internal (attention to one's own body) and external (attention to outside one's own body) increases excitability in the motor cortex, but through mechanisms involving different neurocircuits. This finding has clinical implications for preventive and rehabilitation strategies for disorders of movement as well as pathophysiological characterization of neuropsychiatric disorders. 其他題名： Eur J Neurosci 出版者： France: Blackwell Publishing Ltd 出版日期： 2014-09 出處： The European journal of neuroscience, 2014-09, Vol.40 (5), p.2850-2858 資源來源： Wiley Online Journals ** 版權： 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd 版權： 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. 識別號： ISSN: 0953-816X 識別號： ISSN: 1460-9568 識別號： EISSN: 1460-9568 識別號： DOI: 10.1111/ejn.12651 識別號： PMID: 24946268
Appears in Collections:	[College of Science Institute of Cognitive Neuroscience] journal & Dissertation

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