Lateral prefrontal cortex contributes to maladaptive decisions

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Title:	Lateral prefrontal cortex contributes to maladaptive decisions
Authors:	阮啓弘;Xue, Gui;Juan, Chi-Hung;Chang, Chi-Fu;Lu, Zhong-Lin;Dong, Qi
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Adult;Behavior;Behavioral neuroscience;Biological Sciences;Blood;Brain;Brain - pathology;Brain - physiology;Brain Mapping;Brain Mapping - methods;Cognition;Computer Simulation;cortex;Decision Making;Direct current;Electrophysiology;Electrophysiology - methods;Female;Humans;Magnetic resonance imaging;Magnetic Resonance Imaging - methods;Male;Mental stimulation;methods;Modeling;Neurons;NMR;Nuclear magnetic resonance;Oxygen;Oxygen - blood;pathology;physiology;Prefrontal Cortex;Prefrontal Cortex - physiology;Probabilities;Probability;Random events;Regression Analysis;Social Sciences;Time Factors
Date:	2012-03-20
Issue Date:	2026-04-23 14:29:08 (UTC+8)
Publisher:	National Academy of Sciences;United States: National Academy of Sciences
Abstract:	摘要： Humans consistently make suboptimal decisions involving random events, yet the underlying neural mechanisms remain elusive. Using functional MRI and a matching pennies game that captured subjects’ increasing tendency to predict the break of a streak as it continued [i.e., the "gambler's fallacy" (GF)], we found that a strong blood oxygen level-dependent response in the left lateral prefrontal cortex (LPFC) to the current outcome preceded the use of the GF strategy 10 s later. Furthermore, anodal transcranial direct current stimulation over the left LPFC, which enhances neuronal firing rates and cerebral excitability, increased the use of the GF strategy, and made the decisions more "sticky." These results reveal a causal role of the LPFC in implementing suboptimal decision strategy guided by false world models, especially when such strategy requires great resources for cognitive control. 其他題名： Proc Natl Acad Sci U S A 出版者： United States: National Academy of Sciences 出版日期： 2012-03-20 出處： Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (12), p.4401-4406 資源來源： JSTOR Life Sciences Collection 版權： copyright © 1993-2008 National Academy of Sciences of the United States of America 版權： Copyright National Academy of Sciences Mar 20, 2012 識別號： ISSN: 0027-8424 識別號： ISSN: 1091-6490 識別號： EISSN: 1091-6490 識別號： DOI: 10.1073/pnas.1111927109 識別號： PMID: 22393013
Appears in Collections:	[College of Science Institute of Cognitive Neuroscience] journal & Dissertation

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