Left middle temporal and inferior frontal regions contribute to speed of lexical decision: A TMS study

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Title:	Left middle temporal and inferior frontal regions contribute to speed of lexical decision: A TMS study
Authors:	阮啓弘;Zhu, Zude;Gold, Brian T.;Chang, Chi-Fu;Wang, Suiping;Juan, Chi-Hung
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Adult;Brain;Brain Mapping;Decision Making - physiology;Female;Frontal Lobe - physiology;Functional Laterality - physiology;Humans;Left anterior inferior frontal gyrus;Left middle temporal gyrus;Lexical Access;Lexical Decision Task;Male;Reaction Time - physiology;Response Time;Temporal Lobe - physiology;TMS;Transcranial Magnetic Stimulation;Word Recognition;Young Adult
Date:	2015-02-01
Issue Date:	2026-04-23 14:29:13 (UTC+8)
Publisher:	Academic Press Inc.;United States: Elsevier Inc
Abstract:	摘要： Activation of left anterior inferior frontal gyrus (aLIFG) and left middle temporal gyrus (LMTG) has been observed in some functional neuroimaging studies of lexical decision but not others. It is thus unclear whether these two regions are necessary for word recognition. By applying continuous theta-burst transcranial magnetic stimulation (TMS) which temporally suppresses local brain function, we examined whether aLIFG and LMTG play causal roles in word recognition in a visual lexical decision task (LDT). Furthermore, we manipulated stimulus onset asynchrony (SOA) between prime and target to test whether these regions contribute to word recognition differently. In the LDT task, target words were preceded by semantically related primes (Related Condition; RC) or semantically unrelated words (Unrelated Condition; UC), under both short (150ms) and long (600ms) SOA conditions. TMS of aLIFG and LMTG significantly affected the word recognition speed compared to TMS of Vertex. Our results provide evidence that both aLIFG and LMTG contribute to word recognition speed. Furthermore, at short SOA, TMS of aLIFG or LMTG prolonged reaction time (RT). In contrast, at long SOA, there was a significant region by SOA by TMS interaction such that TMS of aLIFG prolonged RT, whereas TMS of LMTG speeded RT. These results suggest that aLIFG and LMTG may play different roles in word recognition. 其他題名： Brain Cogn 出版者： United States: Elsevier Inc 出版日期： 2015-02 出處： Brain and Cognition, 2015-02, Vol.93 (Feb), p.11-17 版權： 2014 Elsevier Inc. 版權： Copyright © 2014 Elsevier Inc. All rights reserved. 識別號： ISSN: 0278-2626 識別號： ISSN: 1090-2147 識別號： EISSN: 1090-2147 識別號： DOI: 10.1016/j.bandc.2014.11.002 識別號： PMID: 25463244 識別號： CODEN: BRCOEI
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