Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex

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Title:	Modulation of the Disturbed Motor Network in Dystonia by Multisession Suppression of Premotor Cortex
Authors:	黃英儒;Huang, Ying-Zu;Lu, Chin-Song;Rothwell, John C.;Lo, Chung-Chuan;Chuang, Wen-Li;Weng, Yi-Hsin;Lai, Szu-Chia;Chen, Rou-Shayn
Contributors:	生醫理工學院認知神經科學研究所
Keywords:	Accumulation;Achievement tests;Adult;Analysis of Variance;Biology;Brain;Cortex (motor);Cortex (premotor);Deep Brain Stimulation;Deep Brain Stimulation - methods;Dystonia;Dystonic Disorders;Dystonic Disorders - therapy;Experiments;Female;Health aspects;Hospitals;Humans;Hyperactivity;Intervention;Male;Medical research;Medicine;Middle Aged;Motor Cortex;Motor Cortex - physiology;Neural Inhibition;Neural Inhibition - physiology;Neurology;Neuronal Plasticity;Neuronal Plasticity - physiology;Neurosciences;Review boards;Stimulation;Time Factors;Transcranial magnetic stimulation;Treatment Outcome
Date:	2012-10-10
Issue Date:	2026-04-23 14:30:08 (UTC+8)
Publisher:	Public Library of Science;United States: Public Library of Science (PLoS)
Abstract:	摘要： Daily sessions of therapeutic transcranial brain stimulation are thought to prolong or amplify the effect of a single intervention. Here we show in patients with focal hand dystonia that additional, new effects build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. In a sham-controlled study, real or sham continuous theta burst stimulation (cTBS) was given once daily for five consecutive days to dorsolateral premotor cortex (PMd). Five days of real, but not sham, premotor cTBS improved intracortical inhibition in primary motor cortex (M1) to a similar extent on day 1 and day 5. However 5 days of cTBS were required to restore the abnormal PMd-M1 interactions observed on day 1. Similarly, excessive M1 plasticity seen at baseline was also significantly reduced by five days of real premotor cTBS. There was only a marginal benefit on writing. The results show that additional, new effects, at sites distant from the point of stimulation, build up progressively over time, making it difficult to predict the effect of long term interventions from shorter treatment sessions. The results indicate that it may take many days of therapeutic intervention to rebalance activity in a complex network. 其他題名： PLoS One 出版者： United States: Public Library of Science (PLoS) 出版日期： 2012-10-10 出處： PLoS ONE, 2012-10, Vol.7 (10), p.e47574- 資源來源： Agricultural & Environmental Science Collection 版權： COPYRIGHT 2012 Public Library of Science 版權： Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 版權： 2012 Huang et al 2012 Huang et al 識別號： ISSN: 1932-6203 識別號： EISSN: 1932-6203 識別號： DOI: 10.1371/journal.pone.0047574 識別號： PMID: 23071824
Appears in Collections:	[College of Science Institute of Cognitive Neuroscience] journal & Dissertation

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