大腦皮質雙穩態與注意力缺失：清醒慢波的經顱磁刺激-腦電圖研究;Cortical Bistability and Attention Lapses: a Tms-Eeg Investigation of Wake Slow Waves

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题名:	大腦皮質雙穩態與注意力缺失：清醒慢波的經顱磁刺激-腦電圖研究;Cortical Bistability and Attention Lapses: a Tms-Eeg Investigation of Wake Slow Waves
作者:	徐慈妤
贡献者:	國立中央大學認知神經科學研究所
关键词:	注意力缺失;清醒慢波;腦電圖;預設模式網絡;初級運動皮質;經顱磁刺激;attention lapse;wake slow waves;EEG;dorsolateral prefrontal cortex (DLPFC);default mode network (DMN);transcranial magnetic stimulation (TMS)
日期:	2026-07-23
上传时间:	2026-07-27 15:48:00 (UTC+8)
出版者:	國家科學及技術委員會(本會)
摘要:	This project aims to establish the first comprehensive mechanistic account linking wake slow waves, cortical bistability, and attention lapses, advancing fundamental understanding of the neural mechanisms underlying human cognitive performance. Attention deficits are core symptoms of numerous neurological and psychiatric conditions, including depression, sleep disorders, and early-stage neurodegenerative diseases. Current treatments often lack precision because the underlying neural mechanisms remain poorly understood. By identifying objective neural markers of attention lapses, this research may contribute to improved diagnostic tools that detect attention impairments before they manifest behaviorally, personalized treatment approaches that target specific neural mechanisms rather than symptoms, and objective monitoring of treatment efficacy through neural biomarkers of cortical bistability. The TMS-EEG methodology developed in this project also has potential therapeutic applications. Understanding how different brain regions respond to stimulation across cognitive states may inform the development of targeted brain stimulation protocols for patients with pathological attention deficits. These findings may ultimately benefit patients whose quality of life is compromised by attention-related difficulties in work, education, and daily functioning.
關聯:	財團法人國家實驗研究院科技政策研究與資訊中心
显示于类别:	[認知與神經科學研究所 ] 研究計畫

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