辨識磺胺類藥物之溶膠凝膠分子拓印高分子製備與性質研究;Studies on the Preparation and Properties of Sol-Gel Molecularly Imprinted Polymer for Recognized Sulfonamides

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題名:	辨識磺胺類藥物之溶膠凝膠分子拓印高分子製備與性質研究;Studies on the Preparation and Properties of Sol-Gel Molecularly Imprinted Polymer for Recognized Sulfonamides
作者:	陳暉
貢獻者:	化學工程與材料工程學系
關鍵詞:	化學工程類
日期:	2010-07-01
上傳時間:	2010-06-10 17:38:52 (UTC+8)
出版者:	行政院國家科學委員會
摘要:	本計畫擬利用溶膠－凝膠程序（sol-gel process）製備無機分子拓印高分子（Inorganic Molecularly Imprinted Polymer, MIP），以各種不同的磺胺類藥物為模版分子。藉由添加矽偶合劑可使尚未移除模版分子前的結構間產生分子間作用力並具彈性及柔曲性，以提升再鍵結實驗中模板分子的吸附量（adsorption，Ad）和與結構相似物的選擇率（selectivity，α），並訂定拓印指標Ad×α＝f (imprint factor, f)，當拓印指標相對較高時表示同時具有高吸附量與高選擇性。合成之拓印高分子經由萃取或鍛燒的方式將模版分子移除，遺留下具有鍵結辨識位置之微小孔洞，可再次有效地與模版分子產生鍵結，達到模版分子的辨識效果。並以氮氣吸附孔隙儀（Accelerated surface area and porosimetry, ASAP）分析分子拓印高分子之BET表面積與材料之孔隙特性，以進一步更加了解其辨識機制。第一年為高選擇率之無機分子拓印高分子之製備與性質研究-磺胺類藥物之辨識研究，第二年為高選擇率無機分子拓印高分子之製備與性質研究-管柱填充分析之研究，。因此本研究計畫重點擬分二年來加以進行: 第一年計畫重點在以四甲氧基矽烷（tetramethoxysilane, TMOS）或四乙氧基矽烷（tetraethoxysilane, TEOS）為單體，結合矽偶合劑甲基三甲氧基矽烷（methyltrimethoxysilane, MTMOS）或甲基三乙氧基矽烷（methyltriethoxysilane, MTEOS），選用磺胺類（sulfonamides）藥物作為模板分子，利用單體與模版之間的非共價性鍵結-氫鍵（hydrogen bonding）及透過調整pKa的方式以達到更加的辨識效果，並探討無機分子拓印高分子一階段法與二階段法製備、第二階段所調整之pH值、不同R值（H2O/Si molar ratios）、不同方式移除模版分子、各種合成條件的設定以及是否添加模版分子等各種參數以提高對拓印高分子的吸附量和選擇率。第二年計畫重點在以四甲氧基矽烷（tetramethoxysilane, TMOS）或四乙氧基矽烷（tetraethoxysilane, TEOS）為單體，結合矽偶合劑甲基三甲氧基矽烷（methyltrimethoxysilane, MTMOS）或甲基三乙氧基矽烷（methyltriethoxysilane, MTEOS），以磺胺類藥物為模板分子。即以第一年所合成出具高選擇率之分子拓印高分子，藉由另外一種分析方法-管柱填充（packed column）的方式，使得的分離波峰更加明顯尖銳並增長滯留時間，以達到模板與相似物的分離辨識效果。經由變化各種參數，如移動相的比例和pH 值，改變固定相的電荷特性，變化材料之孔洞大小，使製備的無機分子拓印高分子其填充分離效果更加多樣化，並期望無機分子拓印高分子具更加的選擇率與辨識效果。The synthesis of an inorganic molecularly imprinted polymer (MIP) composed of tetramethoxysilane (TMOS) or tetraethoxysilane (TEOS) and the silane coupling agents, methyltrimethoxysilane (MTMOS) or methyl triethoxysilane (MTEOS) for recognize sulfonamides will be studied by sol-gel process. The monomers carrying certain functional groups, which are able to interact either (non-covalently and hydrogen bond) and arranged around the template and ‘frozen’ into position by polymerization with a high degree of cross-linking in the presence of inorganic molecularly imprinted polymer. Removal of the template affords a cavity, which is complementary in size, shape and functionality to the template molecule. We expect to achieve the high adsorption (Ad) and high selectivity (α) in these MIPs. The imprint factor (f) is defined as f = Ad ×α. The imprint factor is an indication to obtain the higher efficiency from adsorption multiplied by selectivity. The BET surface area and pore structure characteristics were determined by Accelerated surface area and porosimetry (ASAP). The major studies of first year: studies on preparation and properties of inorganic molecularly imprinted polymer with high selectivity - research of the molecularly imprinted polymer for recognize sulfonamides by sol-gel process. The major studies of second year: studies on preparation and properties of inorganic molecularly imprinted polymer with high selectivity - research of the molecularly imprinted polymer for recognize sulfonamides by packed column. The research of first year: Inorganic molecularly imprinted polymer based on tetraethoxysilane (TEOS) or tetramethoxysilane (TMOS) and the silane coupling agents will preparation by sol-gel process. The sulfonamides as a template will use in this studies. The conditions of preparation, the H2O/Si molar ratios (R), pH value of competition solution, calcination processes, silane (TMOS and TEOS) and silane coupling agent (MTMOS and MTEOS) molar fractions, the quantity of ammonium hydroxide and so forth will investigate. The research of second year: Inorganic molecularly imprinted polymer based on tetraethoxysilane (TEOS) or tetramethoxysilane (TMOS) and the silane coupling agents for recognize sulfonamides by packed column. The various sulfonamides as a template will use in this studies. We will use a new method, packed column to achieve the higher selectivity and higher recognition efficiency. The conditions of preparation, the mobile phase ratio (MeCN: buffer solution, v/v), the pH value of mobile phase, the electric charge of stationary phase, the porosity of stationary phase and so forth will investigate. 研究期間 : 9808 ~ 9907
關聯:	財團法人國家實驗研究院科技政策研究與資訊中心
顯示於類別:	[化學工程與材料工程學系 ] 研究計畫

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