Pulmonary artery hemodynamics with varying degrees of valvular stenosis: an in vitro study

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Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/26524

Title:	Pulmonary artery hemodynamics with varying degrees of valvular stenosis: an in vitro study
Authors:	Sung,HW;Hsu,TL;Hsu,CH;Hsu,JC
Contributors:	化學工程與材料工程學系
Keywords:	PULSATILE FLOW;MODEL;INVITRO
Date:	1998
Issue Date:	2010-06-29 17:30:03 (UTC+8)
Publisher:	中央大學
Abstract:	The study was to investigate the effects of varying degrees of valvular stenosis on the hemodynamics of the main (MPA), left (LPA), and right (RPA) pulmonary arteries. Particle flow visualization was used to examine the flow patterns in a series of pulmonary artery models manufactured out of glass. These glass models were made based on the geometry of the porcine pulmonary arteries with dilatation in the MPA and LPA. Also, detailed pressure mappings in the models were conducted using a side-hole catheter. As the valve became stenotic, a jet-like flow was observed in the MPA. A higher degree of valvular stenosis corresponded to a narrower jet. This jet-like flow was noted to deflect away from the centerline and impinge on the roof of the dilated MPA. Additionally, a notable pressure gradient across the deflected jet-like flow in the direction of its radius of curvature was seen. Moreover, secondary flows started to appear in the dilated MPA. This suggested that the change in geometry in the MPA, due to its dilatation, had a marked effect on the pulmonary artery hemodynamics. In the LPA and RPA, the strengths of the secondary flows increased as the valve became more stenotic. The flow patterns observed in the LPA appeared to be more disturbed than in the RPA, due to the poststenotic, dilatation present in the LPA. Pressure recovery along the axial direction in the MPA was observed for all the stenotic valves studied. As the degree of valvular stenosis increased, the transvalvular energy loss increased. Moreover: it was observed that the energy loss decreased progressively as the flow traveled downstream. This tendency was consistent with the phenomenon of pressure recovery observed in the pressure measurement. The study demonstrates the importance of analyzing biological flows from a three-dimensional viewpoint. (C) 1998 Elsevier Science Ltd. All rights reserved.
Relation:	JOURNAL OF BIOMECHANICS
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] journal & Dissertation

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