Evaluation of an epoxy-fixed biological patch with ionically bound heparin as a pericardial substitute

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Title:	Evaluation of an epoxy-fixed biological patch with ionically bound heparin as a pericardial substitute
Authors:	Sung,HW;Chang,Y;Chiu,YT;Hsu,HL;Shih,CC;Lu,JH;Yang,PC
Contributors:	化學工程與材料工程學系
Keywords:	HETEROLOGOUS PERICARDIUM;VALVED CONDUIT;HEART-VALVE;COLLAGEN;CLOSURE;GLUTARALDEHYDE;BIOMATERIALS;GRAFTS
Date:	1996
Issue Date:	2010-06-29 17:32:05 (UTC+8)
Publisher:	中央大學
Abstract:	In an attempt to develop an improved pericardial substitute, we undertook the development of an epoxy-fixed biological patch with ionically bound heparin. The study was to evaluate the cross-linking characteristics of this newly developed biological patch using its glutaraldehyde-fixed counterpart as a control. In addition, the feasibility of using this newly developed biological patch as a pericardial substitute was assessed in a canine model. In the study, it was observed that the epoxy-fixed biological patch appeared more similar to the native pericardium in colour and was more pliable than its glutaraldehyde-fixed counterpart. Also, both the epoxy- and glutaraldehyde-fixed biological patches had significant increases in fixation index and denaturation temperature as compared to the fresh one (p < 0.05). In the canine study, the epoxy-fixed biological patch with ionically bound heparin was found to have significantly less adhesion formation than those currently used clinically (p < 0.05). (C) 1996 Elsevier Science Limited
Relation:	BIOMATERIALS
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] journal & Dissertation

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