Enhanced malignant progression of nasopharyngeal carcinoma cells mediated by the expression of Epstein-Barr nuclear antigen 1 in vivo

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Title:	Enhanced malignant progression of nasopharyngeal carcinoma cells mediated by the expression of Epstein-Barr nuclear antigen 1 in vivo
Authors:	Sheu,LF;Chen,A;Meng,CL;Ho,KC;Lee,WH;Leu,FJ;Chao,CF
Contributors:	生命科學研究所
Keywords:	MONOCLONAL-ANTIBODIES;LINES HNE-1;VIRUS;DNA;ASSOCIATION;INVOLUCRIN;EPITHELIA
Date:	1996
Issue Date:	2010-06-29 19:29:08 (UTC+8)
Publisher:	中央大學
Abstract:	Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein-Barr virus (EBV) and mostly classified as poorly differentiated squamous cell carcinoma or undifferentiated carcinoma with early metastasis and a rapidly progressive clinical course. The EBV-encoded latent proteins, Epstein-Barr nuclear antigen 1 (EBNA 1) and latent membrane proteins (LMPs), may be expressed in NPC, but their biological effects are poorly understood. EBNA 1 may predispose B lymphocytes to lymphomagenesis in transgenic mice, but its biological effects in NPC are still unknown. This study investigated the biological effects of EBNA 1 by expressing it in an EBV-negative NPC cell line (HONE-1), which was then inoculated into both nude and severe combined immunodeficiency mice. The EBNA 1 caused HONE-1 cells to grow in a less differentiated pattern and to progress more rapidly, as well as increasing their tumourigenicity and metastatic capability. These data suggest that EBNA 1 may play a critical role in the progressive evolution of NPC.
Relation:	JOURNAL OF PATHOLOGY
Appears in Collections:	[Graduate Institute of Life Science] journal & Dissertation

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