An expert system to classify microarray gene expression data using gene selection by decision tree

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题名:	An expert system to classify microarray gene expression data using gene selection by decision tree
作者:	Horng,JT;Wu,LC;Liu,BJ;Kuo,JL;Kuo,WH;Zhang,JJ
贡献者:	資訊工程研究所
关键词:	METASTATIC BREAST-CANCER;MOLECULAR CLASSIFICATION;BAYESIAN MODEL;TRASTUZUMAB;INFORMATION;MULTICLASS;PREDICTION;DISCOVERY;DATABASES;DISEASE
日期:	2009
上传时间:	2010-06-29 20:13:47 (UTC+8)
出版者:	中央大學
摘要:	Gene selection call help the analysis of microarray gene expression data. However, it is very difficult to obtain a satisfactory classification result by machine learning techniques because of both the curse-of-dimensionality problem and the over-fitting problem. That is, the dimensions of the features are too large but the samples are too few. In this study, we designed an approach that attempts to avoid these two problems and then used it to select a small set of significant biomarker genes for diagnosis. Finally, we attempted to use these markers for the classification of cancer. This approach was tested the approach on a number of microarray datasets in order to demonstrate that it performs well and is both useful and reliable. (C) 2008 Elsevier Ltd. All rights reserved.
關聯:	EXPERT SYSTEMS WITH APPLICATIONS
显示于类别:	[資訊工程研究所] 期刊論文

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