Molecular dynamics simulations of human cystatin C and its L68Q varient to investigate the domain swapping mechanism

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Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/30340

Title:	Molecular dynamics simulations of human cystatin C and its L68Q varient to investigate the domain swapping mechanism
Authors:	Liu,Hsuan-Liang;Lin,Yuan-Min;Zhao,Iian-Hua;Hsieh,Man-Ching;Lin,Hsin-Yi;Huang,Chih-Hung;Fang,Hsu-Wei;Ho,Yih;Chen,Wen-Yih
Contributors:	化學工程與材料工程研究所
Keywords:	AMYLOID ANGIOPATHY;PROTEIN;STABILITY;VARIANT;DISEASE;MODEL
Date:	2007
Issue Date:	2010-07-06 16:17:13 (UTC+8)
Publisher:	中央大學
Abstract:	Human cystatin C variant (L68Q), one of the amyloidgenic proteins, has been shown to form dimeric structure spontaneously via domain swapping and easily cause amyloid deposits in the brains of patients suffering from Alzheimer's disease or hereditary cyst
Relation:	JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Appears in Collections:	[National Central University Department of Chemical & Materials Engineering] journal & Dissertation

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