本文介紹了一種非侵入性且非接觸式的測量系統，用來量測巴金森病患者手背側動脈在懸空及靜止時等四種姿勢下的震動情況。本研究的測量系統主要由一個雷射二極體和一個低成本的互補金屬氧化物半導體（CMOS）影像感測器所組成，而分析方法為雷射線結合質心法和快速傅立葉變換（FFT）。本文貢獻為把多步驟的分析方法融合成一快速且方便的處理方式，並且實驗結果顯示出巴金森氏症患者在手背側動脈的振動波形有明顯的幅度不同和頻率變化。利用雙手測量的方式可以判斷出巴金森氏症病人左腦與右腦的損壞程度。由實驗結果得知，病史與手的震動頻率成正比關係，並且以右手震動頻率較高者居多。而雙手測量的另一個重要貢獻在於減少病人因心理因素或者環境所造成的誤差。由實驗結果得知，以雙手在相同姿勢下量測的震動頻率是比較精準的，經過絕對值運算後巴金森氏症病人扣除雜訊後的平均值為正常人的100多倍，也驗證本實驗室線型光學式三角量測系統的精準性。 My research presents a non-invasive, non-contact system for the measurement of the arterial dorsum manus vibration waveforms of Parkinson disease patients. The laser line method is applied to detect the four dorsum manus vibration in rest and postural situations. The proposed measurement system mainly consists of a laser diode and a low cost complementary metal-oxide semiconductor (CMOS) image sensor. Laser line and centroid methods are combined with the Fast Fourier Transform (FFT) in this study. The contribution of analysis is integrated the multi-step method into a fast and convenient method, and experimental results shown an obvious increase in the amplitude and frequency of dorsum manus variation in the measured region in patients suffering from Parkinson’s disease. The brain damage of Parkinson's disease patients can be determined by the way of using both hands. The experiment results indicate that the disease age is proportional to the frequency of vibration and the right hand is more than left hand. The measurement with both hands has another important contribution to reduce the psychological or environment factors error. The experiment results indicate that the same position with both hands is more accurate and the average frequency of Parkinson's disease patients is more 100 times than normal after computing the absolute value of noise. Therefore, the result also verifies the accuracy of the linear optical triangulation measurement system again.
