Effects of aeration rate on the production of ergosterol and blazeispirol A by Agaricus blazei in batch cultures

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Title:	Effects of aeration rate on the production of ergosterol and blazeispirol A by Agaricus blazei in batch cultures
Authors:	Shu,CH;Lin,KJ
Contributors:	化學工程與材料工程學系
Keywords:	BIOACTIVE POLYSACCHARIDES;SACCHAROMYCES-CEREVISIAE;UNPRECEDENTED SKELETON;SUBMERGED CULTURE;FERMENTATION;MYCELIA;BRASILIENSIS;OPTIMIZATION;BIOREACTOR;MORPHOLOGY
Date:	2011
Issue Date:	2012-03-27 16:26:51 (UTC+8)
Publisher:	國立中央大學
Abstract:	Ergosterol and blazeispirol A are important bioactive components of Agaicus blazei; however, little work in the literature focused on culture conditions on their production. The main aims of this study were to clarify the influence of oxygen transfer rate on cell growth and the production of ergosterol and blazeispirol A and the conversion ratio of ergosterol into blazeispirol A. The optimal aeration rate for cell growth was obtained at 0.4 vvm, while those for ergosterol and blazeispirol A formation were at 0.2 and 0.3 vvm, respectively. The cell growth and blazeispirol A formation favored at higher oxygen supply; but ergosterol formation favored at lower oxygen supply. Results of this study demonstrated oxygen supply played an important role not only in cell growth but also in ergosterol and blazeispirol A formation. A novel fermentation process of blazeispirol A of A. blazei was proposed using a novel parameter, the conversion ratio of ergosterol into blazeispirol A. (C) 2010 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
Relation:	JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
Appears in Collections:	[Department of Chemical and Materials Engineering] journal & Dissertation

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