Cleavage of benzyl ethers by triphenylphosphine hydrobromide

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题名:	Cleavage of benzyl ethers by triphenylphosphine hydrobromide
作者:	Ramanathan,M;Hou,DR
贡献者:	化學學系
关键词:	3,4-DIMETHOXYBENZYL PROTECTING GROUPS;P-METHOXYBENZYL ETHERS;TRIFLUOROACETIC-ACID;SELECTIVE HYDROGENOLYSIS;MPM 4-METHOXYBENZYL;PEPTIDE CHEMISTRY;ALKYL ETHERS;RANEY-NICKEL;EFFICIENT;DEPROTECTION
日期:	2010
上传时间:	2012-03-27 18:07:51 (UTC+8)
出版者:	國立中央大學
摘要:	Triphenylphosphine hydrobromide was found to cleave the benzyl ethers derived from 1 degrees, 2 degrees alkyl, and aryl alcohols to the corresponding alcohols and benzyltriphenylphosphonium bromide in good yields. Alkene and allyl phosphonium salts were produced from the benzyl ethers with 3 degrees alkyl and allyl groups, respectively. These results indicate that the formation of the product is determined by the relative stability of the carbocationic intermediate. The anhydrous, stoichiometric amount of PPh(3)center dot HBr offers a new and effective method for the deprotection of benzyl ethers. (C) 2010 Elsevier Ltd. All rights reserved.
關聯:	TETRAHEDRON LETTERS
显示于类别:	[化學學系] 期刊論文

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