Strength of adhesion clusters under shared linear loading

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题名:	Strength of adhesion clusters under shared linear loading
作者:	Liang,HH;Chen,HY
贡献者:	物理學系
关键词:	DYNAMIC FORCE SPECTROSCOPY;CHEMICAL-REACTIONS;CELL-ADHESION;BONDS;MODEL;SIMULATION;MOLECULES;KINETICS
日期:	2011
上传时间:	2012-06-11 10:52:48 (UTC+8)
出版者:	國立中央大學
摘要:	A cluster of N ligand-receptor pairs between two parallel surfaces under an applied force F = Gamma t with a constant loading rate Gamma is considered. Our theoretical and numerical studies show that there is a characteristic force f(c) and a characteristic loading rate Gamma(c). At Gamma < Gamma(c), the mean rupture force F(r) of the cluster is close to but lower than Nf(c). In this regime, cluster dissociation can be modeled as a one-dimensional barrier crossing process and F(r) scales like Nf(c) - F(r) similar to N(1/3)[ln(Gamma(c)/Gamma)](2/3). At Gamma = Gamma(c), the cluster dissociation occurs at F(r) = Nf(c). At Gamma > Gamma(c), F(r) for clusters with large N is well predicted by the rate equation because the fluctuations of the number of closed bonds are unimportant. Our study shows that f(c) and Gamma(c) are important emergent properties for understanding the mechanical response of adhesion clusters.
關聯:	PHYSICAL REVIEW E
显示于类别:	[物理學系] 期刊論文

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