固相合成的方法最早由R. B. Mrrifile所開創，並因此而獲得諾貝爾獎，近幾年來，由於固相合成方法的快速發展與電腦自動化操作的卓越進步，已使得固相合成方法不僅在醫學領域上引起熱烈的迴響，儼然已成為新藥研發過程中不可或缺的工具，然而在工業界的應用上，由於它的可自動化操作優點，更是開發新型材料的利器。 本篇論文是利用固相合成方法來合成2,4-diphenyl quinazoline系列的衍生物，而此系列分子的物理性質與紫外線吸收劑分子所需之條件相同，故可被應用為一種新型的紫外線吸收劑分子，並將此固相合成方法的合成策略應用於開發此新型紫外線吸收劑分子上，以期望能藉由固相合成方法來開發出具有性質較佳的紫外線吸收劑分子。 Solid phase chemistry is itself a gem with the laureate of Nobel Prize. Now due to the easy accessibility of solid-phase organic synthesis, combinatorial chemistry has revolutionized the world of medicinal chemistry and has now become a must in the field of drug discovery. With the automated implements, it would serve as an even more powerful tool for the discovery of new materials possible for all kinds of applications in the industrial world. In this thesis, combinatorial solid-phase synthesis was applied to develop new materials that are potential UV-absorbers. Based on the 2nd generation hydroxybenzotriazoles and also the 3rd generation hydroxyphenyltriazenes, new molecules were designed and were synthesized on solid supports. Small library of new UV-absorbers were constructed by solid-phase synthesis using a simple, straightforward and successful synthetic schemes in an economic way with respect to time and cost. Characterization of this library has led to lead compounds showing great absorbance (ε=28000) at 327nm which was suitable for stabilizing plastics such as polyacetals, thermoplastic polyesters, unsaturated polyesters and also poly (vinylchloride-co-vinyl acetate). This new series of UV-absorbers is complementary to those stabilizers which are suitable for shorter wavelength application.
