固相組合式合成新穎蛋白質酪胺酸磷酸?1B抑制劑; combinatorial synthesis of novel protein tyrosine phosphatase 1B inhibitor

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6190

Title:	固相組合式合成新穎蛋白質酪胺酸磷酸?1B抑制劑;combinatorial synthesis of novel protein tyrosine phosphatase 1B inhibitor
Authors:	李權芳;Chuan-Fang Li
Contributors:	化學研究所
Keywords:	蛋白質酪胺酸磷酸酶1B抑制劑;訊號傅遞;組合式化學;固相合成;combinatorial chemistry;solid phase synthesis;signal transfer;protein tyrosine phosphatase
Date:	2006-07-08
Issue Date:	2009-09-22 10:15:12 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	許多疾病被研究證實與 PTP 在人體的作用機制失衡有關，例如第二型糖尿病便是與 PTP-1B 有關的典型例子。因而，我們利用固相組合式化學成功設計出一套可快速合成具四種不同變化取代的 5,6-Dihydro-pyran-2-one 及其衍生物，以期能成功模擬 PTP-1B 在生物體中所扮演的角色，並對藥物發展有所貢獻。 There is an evidence that type II diabetes has a connection with insulin resistance. Protein tyrosine phosphatase 1B (PTP 1B) attenuates insulin signal transduction by catalyzing the dephosphorylation of the insulin receptors (IR) and is thus a vital target of potential drug for treatment of type II diabetes. A peptidomimetic sequence targeting at the binding site on PTP 1B combined with a suicide inhibition function is the central concept of our design of potential PTP1B inhibitors. A mini libraries of 5,6-Dihydro-pyran-2-ones was synthesized by a highly efficient scheme which is applicable both in solution-phase synthesis and solid-phase combinatorial synthesis.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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