應用資料探勘於RNA因子及其整合性系統之研製;The Design and Implementation of an Integrated System to Identify RNA Elements

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题名:	應用資料探勘於RNA因子及其整合性系統之研製;The Design and Implementation of an Integrated System to Identify RNA Elements
作者:	洪炯宗
贡献者:	國立中央大學資訊工程系
关键词:	生物科學;資訊科學;軟體
日期:	2012-12-01
上传时间:	2014-03-17 14:15:53 (UTC+8)
出版者:	行政院國家科學委員會
摘要:	研究期間：10108~10207;RNA molecules are involved in numerous biological processes, ranging from gene regulation to protein synthesis. Researching into the functional RNA motifs can obtain useful information for deciphering RNA regulatory mechanisms. Various databases and web servers have accumulated functional RNA motifs during the last few decades, and several approaches have been developed for computational analysis of functional RNA motifs against RNA sequences. However, there is lack of a system integrating these data sources and analytical approaches for comprehensive analysis of functional RNA motifs against RNA sequences. Therefore, we propose an integrated web-based system, fRNAfinder, to facilitate user conveniently and comprehensively analyzing functional RNA motifs against RNA sequences. Though our easy-to-use web server, user can conveniently identify homologs of various known functional RNA motifs against an input RNA sequence, discover conserved RNA motifs against input RNA sequences, and search user-specified RNA motif against numerous RNA sequence databases. Various analytical approaches and data sources were incorporated into fRNAfinder. User can conveniently use these programs without having to download the code and get the programs to run. In addition, three novel approaches, RiboSW, RNALogo and RNAMST, were developed and incorporated to enhance ability of fRNAfinder. RiboSW can efficiently and conveniently identify riboswitches within RNA sequences. RNALogo provides a new graphical representation of the pattern in structural RNA motifs. RNAMST can efficiently and flexibly search user-specified RNA motif against RNA databases. The predictive results and related information are presented with good graphical visualization on fRNAfinder web page. Thus, we suggest that the fRNAfinder is a useful web server which facilitates user conveniently and comprehensively analyzing functional RNA motifs against RNA sequences.
關聯:	財團法人國家實驗研究院科技政策研究與資訊中心
显示于类别:	[資訊工程學系] 研究計畫

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