本論文研究含有不同官能基取代的異吲哚啉，在鈀金屬催化下，進行還原氫化轉換成4,5,6,7-四氫異吲哚時之反應性差異。藉由理論計算與實驗得知，異吲哚啉與吲哚啉於相同反應條件下得到不同的結果，其造成的原因為兩者芳香性有顯著的不同。 This thesis describes the different reactivities of substituted isoindolines in their transformation 4,5,6,7-tetrahydroisoindoles under palladium catalyzed ammonia formate reduction. Significant difference between isoindolines and indolines in this reaction is also revealed and discussed. Theoretical calculations show that aromaticity in isoindoles is much weaker than indoles,which leads to different reaction pathways.
