分子內Michael 加成反應之非鏡像立體選擇性探討與天然物(－)-Allosedridine 和 (－)-2’-epi-Ethylnorlobelol 之合成 Total Synthesis of (－)-Allosedridine and (－)-2’;-epi-Ethylnorlobelol by Diastereoselective Intramolecular Michael Addition

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/6317

Title:	分子內Michael 加成反應之非鏡像立體選擇性探討與天然物(－)-Allosedridine 和 (－)-2’-epi-Ethylnorlobelol 之合成 Total Synthesis of (－)-Allosedridine and (－)-2’;-epi-Ethylnorlobelol by Diastereoselective Intramolecular Michael Addition
Authors:	陳俐如;Li-ju Chen
Contributors:	化學研究所
Keywords:	Michael加成反應;非鏡像立體選擇性;(－)-2'-epi-Ethylnorlobelol;(－)-Allosedridine;diastereoselectivity;Michael addition
Date:	2007-12-06
Issue Date:	2009-09-22 10:17:29 (UTC+8)
Publisher:	國立中央大學圖書館
Abstract:	在本篇論文中，我們利用掌性苯乙胺及其衍生物來控制7-氯-2-庚烯甲酯進行分子內Michael 加成反應時之非鏡像立體選擇性，並且也研究(R)- α-苯乙胺加成至不同官能基之Michael acceptor 時，包括酯類、酮類和Weinreb 醯胺，其非鏡像立體選擇性的差異。最後，並將其應用來合成天然物(－)-allosedridine 和(－)-2'-epi-ethylnorlobelol。 In this thesis, we apply the chiral methylbenzylamine and their derivatives to control the diastereoselectivity of the methyl 7-chlorohept-2-enoate in intramolecular Michael addition reactions. And we also study the differences of the diastereoselectivity when (R)-α-ethylbenzylamine reacts with different Michael acceptors, including the ester, ketone and Weinreb amide. Finally, we apply this methodology to synthesize two natural products (－)-allosedridine and (－)-2'-epi-ethylnorlobelol.
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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