然而在微尺度的研究上，不管是用機械力或外加磁場都並未真正有效達成定向纖維的薄膜控制，且內部的交聯結構並未進行探究，也尚未沒有一個確切的模型，近年來發現在雲母片及二氧化鉬可以使低濃度下的膠原長成單片薄膜，對於膠原蛋白在體外的自組成上的有更加一步地探究模型，這也是我這篇論文最主要的軸心，我們利用此基板的特性為出發點，進行對膠原蛋白結構上可能的控制變因，並設計出了用雷射光的受激拉曼效應使局部材料吸共振吸收，導致局部性的材料加熱，並採用光壓達到薄膜上材料的指向穩定控制。 ;Collagen represents the major structural protein of the extracellular matrix. Elucidating the mechanism of its assembly is important for understanding many cell biological and medical processes as well as for tissue engineering and biotechnological approaches. In this work, conditions for the self-assembly of collagen type I molecules on a supporting surface were characterized. By applying deposition dynamics deposition of collagen on a substrate at room temperature using an appropriate solvent, collagen assembled into ultrathin ( 4nm) highly anisotropic ribbon-like structures coating the entire support. We use stimulated Raman scattering system enables absorption of specific functional groups to allow local resonance absorption, causing local heating of the material, and applying a ponderomotive force to the collagen fibers, in order to achieve a stable directional control.
