在生命科學與醫學研究中，樣品的分析通常包括三個典型步驟，即：樣品分離處理、生物化學反應、結果檢測和分析。現今的實驗室晶片通常只具有執行單一步驟的能力，因此在進行樣品的分析的實驗時，常常需要將專門的樣品晶片、反應晶片、檢測晶片以及微泵和微閥門等元件結合，這不僅耗時、耗費成本而且也可能對實驗造成影響。 因此，本研究提出將驅動器與感測器結合的概念，將介電質電濕式(electrowetting on dielectric, EWOD)微流體系統與導模共振(guided-mode resonance)感測整合至微小晶片上，並且利用整合後的晶片來進行不同濃度的蔗糖液滴訊號量測實驗。由實驗結果得知，本研究製作的晶片不僅成功的將驅動器與感測器結合，而且還能做到動態與即時的量測效果。In life science and medicine research, the assay of the testing samples includes three steps : sample preparation、biochemistry reaction、examination and analysis. Currently, the biochips working with single function require other device such as sample chips、reaction chips、assay chips、micro pump、micro-valve and so on, to perform experiments on assay of the testing sample that are time-consuming and money-wasting. In this work, we propose the concept about integration of actuator and sensor, so the electro-wetting on dielectric (EWOD) micro-fluidic system is integrated with guide-mode resonance (GMR) sensors for the assay of sucrose aqueous solution. The optical spectrum analyzer (OSA) data reveals that the integrated chip works normally, also can achieve in-situ detection.
