以有機催化2-吡啶酮具鏡像選擇性共軛加成反應之探討

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/74041

Title:	以有機催化2-吡啶酮具鏡像選擇性共軛加成反應之探討
Authors:	鐘毅;Jhong, Yi
Contributors:	化學學系
Keywords:	以有機催化2-吡啶酮具鏡像選擇性共軛加成反應之探討
Date:	2017-08-23
Issue Date:	2017-10-27 13:00:21 (UTC+8)
Publisher:	國立中央大學
Abstract:	本篇是以有機鹼做為催化劑，藉由合成多種辛可寧衍生出的掌性催化劑來激發2-吡啶酮進行不對稱1,4加成到Michael acceptor上，期望可以得到高產率及鏡像選擇性，其中以辛可寧錠的方醯胺衍生物可以帶來最高的效益，產率可達96%，鏡像選擇性可達93%。;A series of cinchonidine drived catalysts were synthesized from cinchonine . Under the optimal conditions, a cinchonidine-based squaramide was found to be an excellent catalyst for the enantioselective aza-Michael addition of 5-chloro-2-hydroxypyridine with various Michael acceptors. This approach yielded high enantioselectivity (up to 93%) and yield(up to 96%).
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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