我們成功以鈀金屬催化含氮炔類化合物進行分子內合環形成環戊 烷取代吡咯衍生物，且使用微波反應器輔助可以有效提升產率，最高可 達92%。此方法可應用於合成藥物Ramipril 中的重要結構。;Hydroamination of N-(2-ethynylcyclopentyl)sulfonamide to give non-aromatic 2,3-dihydropyrroles was achieved by using PdCl2 as the catalyst. With microwave-assisted heating, up to 92% isolated yield was obtained from this intramolecular 5-endodig cyclization. The cyclopentane-fused 2,3-dihydropyrroles were transformed into the corresponding N-tosyl-pyrrolidine-2- carboxylic acids.
