雙離子胺基酸吸附劑在血液中重金屬 吸附之應用;Amino acid-base hydrogel: A heavy metal ion scavenger in blood

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题名:	雙離子胺基酸吸附劑在血液中重金屬吸附之應用;Amino acid-base hydrogel: A heavy metal ion scavenger in blood
作者:	方雲龍;Fang, Yun-Lung
贡献者:	生醫科學與工程學系
关键词:	氨基酸;水凝膠;銅吸附劑;兩性離子材料;血液相容性;透析;amino acid;hydrogel;copper adsorbent;zwitterionic material;dialysis;hemocompatibility
日期:	2018-01-26
上传时间:	2018-04-13 10:52:28 (UTC+8)
出版者:	國立中央大學
摘要:	重金屬污染是當今最重要的環境問題之一，含銅廢水常由農業中農藥噴灑、粉刷顏料和皮革工業生產的過程中未經處理直接排放到自然環境，經由食物鏈的堆積時將嚴重影響人體的健康，例如阿爾茨海默病、帕金森病或威爾森氏症。藥物螯合被廣泛用於治療銅超載疾病，但據報導其具有破壞免疫系統、腎臟，並可能使已有神經問題的患者的神經症狀惡化…副作用等。在先前的研究中以證明雙離子氨基酸的聚合物具有優異的生物相容性和防污性能且能夠藉由其官能基專一的螯合銅離子。在這裡，我們開發了一種基於氨基酸的水凝膠吸附劑，並將其填充至管柱方便快速過濾患者血液中的銅離子。我們在不同條件下進行了胺基酸吸附劑對Cu2 +的螯合能力，並藉由溶血試驗和血小板粘附實驗證實了血液相容性，最後通過動物實驗驗證了其去除溶液中的銅離子之效果。我們期望此氨基酸吸附劑在將來能作為Cu2+ 清除劑及在血液透析上的應用。 ;Heavy metal pollution has been one of the most important environmental problems today. Copper-containing wastewater is extensively released from different industries. The release of metal ions into food chains results in serious healthcare issues such as overaccumulation in human body leading to Alzheimer′s, Parkinson′s and Wilson diseases. Pharmaceutical chelating agents are widely used in the treatment of copper-induced toxicity. However, it had been reported that the side effects of the treatment damage the immune system, kidneys and neurological symptoms of patients with pre-existing neurological problems. Zwitterionic amino acid-based polymers were developed for excellent biocompatibility and antifouling properties. In previous studies, amino acid group enables specifically catching copper ions from solution by formation of a chelating structure. Here, we developed an amino acid-based hydrogel adsorbent in order to rapid and effective removal of Cu2+ ions from blood by filtration in a gel-packed column. We performed the chelating ability of gel adsorbent to Cu2 + under different conditions and confirmed the hemocompatibility by hemolysis test and platelet adhesion test. Finally, we verified the capability of gel column to remove copper ions from the solution in an animal experiment. As result, it owns good adsorption and regeneration ability, and good hemocompatibility and it also can sorption copper in blood. We expect that the amino acid-based hydrogels hold a great potential as a Cu2+-removal hemodialysis system in the future.
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