;Abstract In recent years, cases of medical disputes have emerged in an endless stream. News of intense medical disputes between patients and physicians have been heard from time to time. In the process of rapid social changes, trust between doctors and patients has been declining. This dissertation analyzes the principle of autonomy under the concept of "trust" and emphasizing patient′s autonomy in patient-physician interaction. This paper also discusses the trust relationship of principlism (Tom Beauchamp and James F. Childress) and Onora O′Neill′s “principled autonomy” as a reconstruction of the principle according to Kant’s original meaning. Trust issues. At the same time, O′Neill believes that the interpretation of the principle of autonomy as obligation not only is more in line with Kant′s original intentions, but also that obligations or responsibilities do not defy rights, and rather it demonstrates better the importance of interpersonal integration of the principle of self-discipline. We can thus establish a principle of self-discipline that can promote interpersonal relationships, especially the relationship of trust between doctors and patients. However, O′Neill neglects the importance of the relation of intimacy and trust between doctors and patients and still risks and the lack of ethical concerns because of lack of sympathy. Therefore, I interpret the relationship between doctors and patients with the concept of ren (benevolence) in Confucian ethics and expand the use of the viewpoint of treating patients as family members in the view of the Tang Dynasty doctor Sun Sie-yi. I introduce the Confucian concept of “ethical relational autonomy” as it is developed by Professor Shui Chuen Lee in response to the lack of mutual concerns mentioned above. Finally, I try to assess the contribution of trust by the “Patient Autonomy Rights Ac.t”. Doctors should empathize with the feelings of empathy and sympathy to ease the doubts of patients and their families. The emotional and caring nature of the heart can also explain the Confucian spirit of “benevolence”, make the interaction between doctors and patients more harmonious, and rebuild the trust physician-patient relationship。