| 摘要: | 就目前醫學的有限知識中，大腦是最為複雜與精密的人類器官。其扮演著許多重要疾病起因的角色，其中之一即為中風，而其所引發的認知缺陷即包含癡呆症。在台灣，該致病率不僅是在台灣甚為嚴重並造成健保系統的龐大負擔，甚至世界衛生組織亦將其列為重點研究與防治的項目。目前在臨床治療腦中風的過程中，有兩個重要因素需瞭解並預測更多的資訊，以幫助醫師做臨床診斷或手術計畫擬定使用。此其一要素為瞭解腦血流如何灌注顱內，並提供腦細胞足夠的氧氣以維持其正常工作。而另一要素則是由於目前醫學影像設備技術有限，若欲瞭解並預測腦中風之結果，需發展相當高解析度之顱內血管造影技術。然而，此部分學界雖有部分團隊，正在發展相關影像處理之演算法，但考慮使用大腦多孔力學模型模擬呈現相關結果亦不失為另一途徑。本研究將基於前期科技部所支助繼續開發台灣版之虛擬大腦生理資訊系統，使用考慮流－固耦合條件之大腦多孔力學模型並搭配動物實驗加以驗證之。進而將此計畫之技術平台應用於國內外皆至為重要之科學研究議題–缺血性腦中風。預計前二年完成三維流固耦合含流場軟體及建立動物模型實驗平台，於第三年時除將兩者結果相互驗證外，並會嘗試探討與血管性失智症之關連性。 ;Within the spectrum of biomedical research, the human brain is the most complex and sophisticated organ. It plays a crucial role in many important diseases, the most pertinent of which are Stroke and Dementia. In Taiwan, the pathogenic rate is not only severe, but it also accompanied by being a sizeable burden on the health care system. The extent of the latter has prompted the World Health Organization (WHO) to list it as a critical research and prevention project for Taiwan. At present, in the clinical treatment process of stroke, two essential factors need to be known in order for the prediction of information to be helpful for physicians to make correct decisions regarding the clinical diagnosis and/or make the surgical plan. The first is to understand how the cerebral blood flow perfuses and provides sufficient oxygen to the cerebral cells in order to maintain their functionality, whilst the second is that the current equipment and technology in the medical imaging domain is limited. To understand and predict the outcome of stroke, a relatively high-resolution intracranial angiography technique needs to be developed. Interestingly, an alternative pathway to impact exists via the use of cerebroporomechanics models, as these can be shown to cater for the issue of the cost-performance ratio. This study will build on the previous project awarded by Ministry of Science and Technology (MOST), which allowed for the development of the virtual physiological human information system in the brain. Specifically, the use of a cerebroporomechanics model that couples the fluid-solid interaction (FSI) conditions and verifies these with animal experiments will be pursued. Furthermore, this framework will be applied to tackle one of the most important scientific topics, both national as well as international: ischaemic stroke. It is expected that the 3D FSI-based cerebroporomechanics model, along with the establishment of the rat model of ischaemic stoke of the experimental platform will be completed in the first and second year, respectively. In the third year, in addition to verifying the results via the data from the previous two years, we also attempt to explore the relationship between ischaemic stroke and vascular dementia. |
