以開環置換聚合反應合成手性共價有機框架材料並將其應用於不對稱催化多烯環化反應之研究;Synthesis of Chiral Covalent Organic Frameworks via Ring-Opening Metathesis Polymerization and Its Application Study in Asymmetric and Catalytic Polyene Cyclization

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/90294

Title:	以開環置換聚合反應合成手性共價有機框架材料並將其應用於不對稱催化多烯環化反應之研究;Synthesis of Chiral Covalent Organic Frameworks via Ring-Opening Metathesis Polymerization and Its Application Study in Asymmetric and Catalytic Polyene Cyclization
Authors:	曾宥勲 Tseng, Yu-Hsun
Contributors:	化學學系
Keywords:	中孔洞碳材;生質碳材;金屬氧化物;鋰離子電池;鈉離子電池;負極材料;Mesoporous carbon;Biomass carbon;Metal oxide;Lithium ion battery;Sodium ion battery;Anode material
Date:	2022-08-16
Issue Date:	2022-10-04 12:57:53 (UTC+8)
Publisher:	國立中央大學
Abstract:	大自然中部份天然物為多環化合物，這類化合物擁有良好的生物活性以及藥物開發潛力，因此建構出具有立體選擇性的多環主結構成為化學家追求的目標。本論文目的在於開發新型手性共價有機框架材料，並應用至不對稱多烯環化反應上。以 R 型 1,1′-聯-2-?酚之衍生物作為催化單體，並使用格拉布二代試劑將帶有降??烯基的催化單體和架橋分子進行開環置換聚合反應。此法合成的手性共價有機框架材料以碳碳雙鍵鏈接起材料骨架，與四氯化錫進行配位後，形成路易士酸輔助手性布式酸並投入不對稱多烯環化反應上，經不同反應條件篩選後，最終環化產物可超過 40% 的鏡像超越值。 ;Polycyclic scaffolds are frequently seen in natural products and drugs; therefore, developing synthetic strategies and methods for constructing these scaffolds are essential, especially in an enantioselective way. In this thesis, we aimed to develop a new chiral covalent organic framework (CCOFs), and apply it to enantioselective polyene cyclization. (R)-Binol with norbornenes on the two arms was used as a monomer and polymerized by using Grubbs second-generation catalyst through ring-opening metathesis polymerization (ROMP) for the formation of CCOF. After treating Tin chloride to generate a Lewis acid-assisted chiral Bronsted acid complex, the activated CCOF was applied to the enantioselective polyene cyclization. Different reaction conditions were then screened to provide, the best result with more than 40% enantiomeric exces
Appears in Collections:	[Graduate Institute of Chemistry] Electronic Thesis & Dissertation

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