| 摘要: | 聚醚醚酮(Polyetheretherketone, PEEK)是一種廣泛用於生物醫學領域的熱塑性高分子聚合物，由於其優異的機械性能，其擁有較為接近人體骨小樑的彈性模數，這可以大大降低應力屏蔽效應並減少骨吸收和植入物的潛在鬆動，且因其加工成型效果及高溫耐久性佳，亦可做為積層製造(Additive Manufacturing, AM)的適當材料。然而，因 PEEK 具有生物惰性，這會導致其與周遭細胞組織的黏附性較差，因此需要將生物活化物添加入其中以改善其生物活性。羥基磷灰石(Hydroxyapatitie, HA)作為一種具有高度生物活性及生物相容性的生醫材料，適合作為改善 PEEK 生物活性的材料。本研究結合 AM 技術，改良了本實驗室先前用於 PEEK 試片的表面改質方式。首先，為了使得 HA 材料能夠用於 AM 系統，在列印前，本研究利用聚乳酸(Polylactic, PLA)作為 HA 粉末的載體，開發了一種新的線材製作方式。透過事先將顆粒狀的 PLA 溶於二氯甲烷並以乙醇析出，將 PLA轉化為粉末狀態，使其得以順利作為載體與 HA 粉末混合，並製作成 PLA/HA 複合粉末。隨後，以壓錠的方式使 PLA/HA 複合粉末壓縮成圓餅錠，並將錠製成PLA/HA 複合線材。為了最大的提升 PEEK 試片的親水性，本研究想盡量提高PLA/HA 線材內的 HA 含量，透過上述的線材製作方式，本研究成功做出了含有最高 50 wt%HA 含量的 PLA/HA 複合線材。最後，以本實驗室先前的研究為基礎，提出了一種新的表面改質方法，修改原本 PLA/HA 線材的列印路徑，順利使得具有高 HA 含量的 PLA/HA 複合材料能夠順利附著在 PEEK 試片表面。並在經過清洗及研磨等一系列後處理後，成功使得 PEEK 試片之親水性提升 43.56%至 65.16%。;PEEK is a thermoplastic polymer widely used in the biomedical field. Due to its
excellent mechanical properties, its elastic modulus is close to the elastic modulus of
trabecular bone, which will greatly reduce the stress shielding effect and then reduce
bone resorption and potential loosening of the implant. In addition, due to its good
processing and molding effect and high temperature durability, it can also be used as a
suitable material for Additive Manufacturing. However, because of its bio-inert, which
will result in poor adhesion to surrounding cells and tissues, bioactive materials need
to be added to improve its biological activity. Hydroxyapatite (HA), as a biomedical
material with high bioactivity and biocompatibility, is suitable as a material to improve
the bioactivity of PEEK. This study combines AM technology and improve the surface
modification method previously used for PEEK specimens in our laboratory. First, in
order to enable HA materials to be used in AM systems, this study developed a new
filament production method using polylactic acid as a carrier for HA powder before
printing. By dissolving the granular PLA in methylene chloride and precipitating it with
ethanol in advance, the PLA is converted into a powder state so that it can be smoothly
mixed with the HA powder as a carrier to produce a PLA/HA composite powder.
Subsequently, the PLA/HA composite powder is compressed into a round cake tablet
by pressing, and the tablet is made into a PLA/HA composite filament. In order to
maximize the hydrophilicity of the PEEK specimens, this study want to increase the
HA content in the PLA/HA filament as much as possible. Through the above filament
production method, this study successfully made PLA/HA composite filament with the
highest HA content of 50 wt%. Finally, based on previous research in this laboratory,
this study proposes a new surface modification method to modify the original printing path of PLA/HA filaments, so that PLA/HA composite materials with high HA content
can be smoothly attached to the surface of PEEK specimens. After a series of postprocessing such as cleaning and grinding, the hydrophilicity of the PEEK specimens
were successfully increased by 43.56% to 65.16% |
