Morphology and organization of tissue cells in 3D microenvironment of monodisperse foam scaffolds

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/50952

Title:	Morphology and organization of tissue cells in 3D microenvironment of monodisperse foam scaffolds
Authors:	Lin,JY;Lin,WJ;Hong,WH;Hung,WC;Nowotarski,SH;Gouveia,SM;Cristo,I;Lin,KH
Contributors:	生物物理研究所
Keywords:	3-DIMENSIONAL SCAFFOLDS;EXTRACELLULAR-MATRIX;POLYMER SCAFFOLDS;CULTURE;BONE;BEHAVIOR;ARCHITECTURE;FABRICATION;ELASTICITY;MIGRATION
Date:	2011
Issue Date:	2012-03-27 18:13:34 (UTC+8)
Publisher:	國立中央大學
Abstract:	Here we demonstrate an efficient method to fabricate large-domain monodisperse foam scaffolds made of gelatin for 3D cell culture. We tested three distinct tissue cell types cultured in foam scaffolds composed of uniform spherical pores. The cells displayed appropriate morphological and physiological characteristics: epithelial cells formed cyst-like structures and were polarized inside pores, myoblasts adopted a tubular structure and fused into myotubes, and fibroblasts exhibited a wide variety of morphologies. Scaffolds with uniform pores can thus provide a platform for systematic study of 3D cell-matrix interactions.
Relation:	SOFT MATTER
Appears in Collections:	[Graduate Institute of Biophysics] journal & Dissertation

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