Morphology and organization of tissue cells in 3D microenvironment of monodisperse foam scaffolds

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题名:	Morphology and organization of tissue cells in 3D microenvironment of monodisperse foam scaffolds
作者:	Lin,JY;Lin,WJ;Hong,WH;Hung,WC;Nowotarski,SH;Gouveia,SM;Cristo,I;Lin,KH
贡献者:	生物物理研究所
关键词:	3-DIMENSIONAL SCAFFOLDS;EXTRACELLULAR-MATRIX;POLYMER SCAFFOLDS;CULTURE;BONE;BEHAVIOR;ARCHITECTURE;FABRICATION;ELASTICITY;MIGRATION
日期:	2011
上传时间:	2012-03-27 18:13:34 (UTC+8)
出版者:	國立中央大學
摘要:	Here we demonstrate an efficient method to fabricate large-domain monodisperse foam scaffolds made of gelatin for 3D cell culture. We tested three distinct tissue cell types cultured in foam scaffolds composed of uniform spherical pores. The cells displayed appropriate morphological and physiological characteristics: epithelial cells formed cyst-like structures and were polarized inside pores, myoblasts adopted a tubular structure and fused into myotubes, and fibroblasts exhibited a wide variety of morphologies. Scaffolds with uniform pores can thus provide a platform for systematic study of 3D cell-matrix interactions.
關聯:	SOFT MATTER
显示于类别:	[生物物理研究所 ] 期刊論文

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