本篇論文發展一新方法：利用氯化鈀作為催化劑，以含苯甲酸之烯化合物作為起始物，進行烯烴異構化反應。且反應後的碳-碳雙鍵為單一E-from結構，產率達92%。應用此反應，以掌性雙烯雙醇化合物5作為起始物，合成天然物Aigialomycin D之差向異構物5′-epi-Aigialomycin D (1)。其中碳-碳鍵的生成以交叉置換反應 (Cross Metathesis) 完成，大環內酯以Yamaguchi內酯化反應建構。;A novel palladium-catalyzed isomerization of alkenylbenzoic acid has been developed. This methodology could be applied to synthesis 5′-epi-Aigialomycin D by using chiral dienediol 5 as the starting material. The key reactions included cross metathesis (CM) and Yamaguchi lactonization.
